WebNational Center for Biotechnology Information WebMay 4, 2024 · Introduction. Siglecs (sialic acid binding immunoglobulin-like lectins) are among the immune regulatory molecules that control ongoing inflammation (Macauley et al. 2014; Schnaar 2016).All siglecs bind to sialoglycans and most are immune inhibitory, with intracellular immunoreceptor tyrosine-based inhibitory motifs (ITIMs).
National Center for Biotechnology Information
WebOct 11, 2024 · Authors: Wang, Xiaocong; Hanes, Melinda S.; Cummings, Richard D.; Woods, Robert J. Award ID(s): 1933525 Publication Date: 2024-10-11 NSF-PAR ID: 10406406 Journal Name ... WebOct 3, 2024 · Aberrant accumulation and activation of eosinophils and potentially mast cells (MCs) contribute to the pathogenesis of eosinophilic gastrointestinal diseases (EGIDs), … sharpie storage
Anti–Siglec-8 Antibody for Eosinophilic Gastritis and Duodenitis
WebApr 10, 2024 · The emerging importance of the Siglec-sialic acid axis in human disease, especially cancer, has necessitated the identification of ligands for Siglecs. Recombinant Siglec-Fc fusion proteins have been widely used as ligand detectors, and also as sialic acid-targeted antibody-like proteins for cancer treatment. However, the heterogenetic … WebSiglec-8 is a member of the family of cell surface receptors called Sialic acid-binding immunoglobulin-type lectins (Siglecs). Siglec-8 is found on the surface of mature mast cells and mature eosinophils, and therefore offers … WebFeb 18, 2024 · Their role in cancer is poorly investigated, and research focusses on Siglec-expression on immune cells interacting with tumor cells. This study evaluates the role of … sharpie storage ideas