Dkk1 molecular weight
WebSep 20, 2004 · Oncogene - DKK1, a negative regulator of Wnt signaling, is a target of the β-catenin/TCF pathway ... Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The ... WebMay 28, 2009 · DKK1 migrated at an apparent molecular weight of 40 to 50 kDa, slightly larger than its predicted molecular weight of 30 kDa but clearly monomeric. In contrast, when DKK1 was coinjected with LRP6-ECD, a portion of DKK1 comigrated with LRP6 ECD at a molecular weight of ≈200 kDa ( Figure 5 A), indicating an interaction between …
Dkk1 molecular weight
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WebApr 5, 2024 · In this study, to further explore the molecular mechanisms responsible for the 5FU resistance in CRC, we first analyzed the Wnt/β-catenin signaling pathway genes in an expression profiling dataset from CRC patients (GSE52735) who either responded or did not respond to 5FU, which led us to identify that overexpression of DKK1 gene was a ... WebMar 21, 2024 · Complete information for DKK1 gene (Protein Coding), Dickkopf WNT Signaling Pathway Inhibitor 1, including: function, proteins, disorders, pathways, orthologs, and expression. ... Gene Ontology (GO) - Molecular Function for DKK1 Gene. GO ID Qualified GO term Evidence PubMed IDs; GO:0005515 3 5: enables protein binding: IPI: …
Web267 CHAPTER 8 CONCLUSIONS AND RECOMMENDATIONS FOR FUTURE RESEARCH The conclusions, in summary, are broadly grouped into the following sections in line with the specific objectives of this research, na[.] - 123doc - thư viện trực tuyến, download tài liệu, tải WebThe calculated molecular weight of Recombinant Human DKK-1 expressed in HEK293 cells is 25.8 kDa. Source: HEK293 cells Synonyms: Dickkopf-related protein-1, Dickkopf …
WebApr 8, 2024 · Although the mechanism of DKK1 in regulating Wnt signaling is unclear, importantly, DKK1 overexpression has been observed in ... molecular glue could complement PROTACs with far more advantages in terms of molecular weight than PROTACs . In this context, a recent study reports β-catenin’s molecular glue. Usually, … WebTarget Information. DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head-forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play important regulatory roles in the Wnt/beta-catenin signaling ...
WebApr 14, 2024 · In this study, we explored the role and molecular mechanisms of Dkk1 in VC based on a smooth muscle-specific Dkk1-knockout (Dkk1SMKO) mouse model. Our data indicated that Dkk1 expression was decreased under calcifying conditions and that Dkk1 overexpression alleviated high phosphate-induced vascular calcification.
WebDKK1 (dickkopf WNT signaling pathway inhibitor 1) is one of the four members of the evolutionary conserved small gene family called DKK. DKKs are secreted glycoprotein composed of 255–350 amino acids (aa) and a molecular weight between 24 and 29kDa for DKK1. All DKKs are composed of two conserved cysteine-rich domains and a leader … right flank pain meaningWebCalculated molecular weight: 266 aa, 29 kDa: Observed molecular weight: 30-35 kDa: GenBank accession number: BC001539: Gene … right flank pain menWebApr 14, 2024 · By qPCR assay, we found an upregulation of β-catenin downstream target genes (Axin2 and Dkk1) and other chemokine genes (Ccl3, Ccr1, Ccr5, Cxcr1, Cxcr2 but not Ccl5) in a dose-dependent manner in ... right flank pain nhsWebThe MA5-15497 immunogen is purified recombinant fragment of DKK1 expressed in E. Coli. MA5-15497 detects DKK1 which has a predicted molecular weight of approximately 28.7kDa. Target Information DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head … right flank pain radiating to shoulderWebMolecular Weight: 42 kDa Purity: >95% as determined by SDS–PAGE analysis. Amino Acid Sequence: TLNSVLNSNA IKNLPPPLGG AAGHPGSAVS AAPGILYP GG … right flank pain symptomWebAntonio Barbáchano, ... Alberto Muñoz, in Vitamin D (Fourth Edition), 2024. Upregulation of DKK1. 1,25(OH) 2 D 3 induces the expression of the DKK1 gene in CRC cells, and there is a significant direct correlation between VDR and DKK1 RNA expression in tumor biopsies from CRC patients [100]. DKK1 belongs to the DICKKOPF gene family that encodes … right flank pain when bendingWebSelected: Rabbit DKK1 Antibody $ 1,595.00 $ 795.00 1,595.00 $ 795.00. Rabbit DKK1 Antibody quantity right flank pain radiating to lower abdomen